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Published on: 1985-10-03
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Original language: English

The diversity of antigen-binding structures of antibody molecules is so vast that every conceivable antigen can be bound by an antibody molecule within the immune system. This is true even for the antigen binding sites of antibodies called idiotypes, which are bound by complementary bind­ ing sites of other antibodies called anti-idiotypes. Thus, anti-idiotypes are structural homologues of antigens. These idiotypic-anti-idiotypic interactions constitute a network within the immune system. Since one lymphocyte produces only one type of antibody molecule, this network is in fact a network of cells. We expect that the network is functional: the appearance of antigen will disturb the equilibrium of the network at the point where it competes with the anti­ idiotypic lymphocyte for binding to the idiotypic lympho­ cyte. It has been known for quite some time that anti­ idiotypic antibody can be used to prime the immune system for memory to an antigen that it has never seen. This phe­ nomenon is now being explored for possible use in immuni­ zation against viruses, bacteria, parasites and tumors as well as for the modulation of autoimmunity. The ability of anti-idiotypes to mimic, both antigenically and function­ ally, the corresponding biologically active molecules seen by an idiotypic antibody was first demonstrated for the hormone insulin and is now being observed in many other systems. The papers assembled in this volume· bring the reader to the cutting edge of the potential practical applica­ tions of the network theory of the immune system. Resolve a DOI Name Type or paste a DOI name into the text box. Click Go. Your browser will take you to a Web page (URL) associated with that DOI name. Send questions or comments to doi ... Home - Springer Providing researchers with access to millions of scientific documents from journals books series protocols and reference works. Endogenous Antimicrobial Peptides and Skin Infections in ... Background The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and -defensins. In normal skin these peptides are ... USA - Scientific Conferences & Events Organizer omics group has scheduled its 2014 2015 and 2016 international and scientific conferences meetings events workshops and symposiums in america europe asia ... Biology Flashcards - Flashcard Machine Flashcard Machine - create study and share online flash cards My Flashcards; Flashcard Library; About; Contribute; Search; Help; Sign In; Create Account Microscopy ListServer Archive Output Since I decided to bit the bullet and try to get this system working let me post the first real message to the Microscopy Listserver. ... Course Directory Catalog 2014-2015 - Lamar University College of Education and Human Development. Education and Human Development College Overview. Department of Counseling and Special Populations The Causes Of Over 200 Diseases by John ... - Cause of Disease Causes Of Over 200 Diseases. by John Austin Health Researcher Author and Certified Nutritionist Antiinflammatory Action of Glucocorticoids New ... Glucocorticoids are among the most common therapeutic agents used in medical practice yet their mechanisms of action are only partly understood. This review ... Books@Ovid 100 Cases for Medical Data Interpretation; 100 Cases in Acute Medicine; 100 Cases in Dermatology; 100 Cases in General Practice; 100 Cases in Orthopaedics and ...
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